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KMID : 1144820180240020102
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대한의생명과학회지
2018 Volume.24 No. 2 p.102 ~ p.107
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Cardamonin Inhibits the Expression of Inducible Nitric Oxide Synthase Induced by TLR2, 4, and 6 Agonists
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Kim Ah-Yeon
Shim Hyun-Jin
Kim Su-Yeon
Heo Sung-Hye
Youn Hyung-Sun
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Abstract
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Toll-like receptors (TLRs) play an important role for host defense against invading pathogens. The activation of TLRs signaling leads to the activation of NF-κB and the expression of pro-inflammatory gene products such as cytokines and inducible nitric oxide synthase (iNOS). To evaluate the therapeutic potential of cardamonin, which is a naturally occurring chalcone from Alpinia species (zingiberaceous plant species), NF-κB activation and iNOS expression induced by MALP-2 (TLR2 and TLR6 agonist) or LPS (TLR4 agonist) were examined. Cardamonin inhibited the activation of NF-κB induced by MALP-2 or LPS. Cardamonin also suppressed the iNOS expression induced by MALP-2 or LPS. These results suggest that cardamonin has the specific mechanism for anti-inflammatory responses by regulating of TLRs signaling pathway.
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KEYWORD
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Cardamonin, Inducible nitric oxide synthase, TLR, Inflammation, LPS
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